A 24–4 win over the Canberra Raiders at home followed before the Titans lost its first match of the season against the North Queensland Cowboys in Townsville.
The Titans bounced back a week later to beat the Melbourne Storm at home before stumbling against the St. George Illawarra Dragons in round six.
They defeated the New Zealand Warriors easily 28–16 and as a result earned a week off (two of the top three teams lost on the weekend) and a home preliminary final at Suncorp Stadium.
Unfortunately, the Titans saved their worst for last, losing 32–6 against the Sydney Roosters who progressed to the Grand Final a season after finishing last.
After playing the Titans last few matches of the 2010 NRL season with a broken thumb, Luke Bailey was awarded his second Paul Broughton Medal for the club's player of the year.