It competed in the National Rugby League's 2010 Telstra Premiership and finished 9th out of 16 teams, only just missing out on a place in the finals.
English Recruit Sam Burgess picked up his first try in Rabbitohs colours; Adam Reynolds, Jason Clark, Brock Molan, Kennedy Pettybourne, Josh Mansour, Curtis Johnston and Matt Mundine each scored a try.
[1] Two weeks later the Rabbitohs took their pre-season to Coffs Harbour, New South Wales to play the Gold Coast Titans at BCU International Stadium in front of 5,500 supporters.
[2] The Rabbitohs then took part in the traditional Charity Shield clash against the St George Illawarra Dragons.
The following list comprises players who were in the Rabbitohs full-time first-grade squad for the 2010 season in the NRL Telstra Premiership.