The Parramatta club finished the regular season in 12th place failing to make the finals for the first time in two years.

The Parramatta Eels were picked at the beginning of the year by many leading betting agencies to take out the premiership for 2010 following their surge of form which took them to the Grand Final in 2009.

After a season of unrelenting disappointment which saw five-eighth Daniel Mortimer dropped to reserve grade, centre Timana Tahu being suspended for an on-field confrontation against the Newcastle Knights and reports of player rifts, Daniel Anderson was sacked unceremoniously as Parramatta coach and replaced by New Zealand World Cup-winning coach Stephen Kearney.

[1] The playing squad and coaching staff of the Parramatta Eels for the 2010 NRL season as of 31 August 2010.

[2] 585 Nathan Cayless – PR (c) 595 Nathan Hindmarsh – SR (c) 602 Luke Burt – WG 608 Eric Grothe, Jr. – WG 665 Fuifui Moimoi – PR 673 Feleti Mateo – LK 674 Ben Smith – SR 679 Timana Tahu – CE 683 Joel Reddy – CE 690 Jarryd Hayne – FB 695 Krisnan Inu – CE 700 Matt Keating – HK 701 Brendan Oake – SR 702 Kris Keating – FE 705 Tim Mannah – PR 706 Jeff Robson – HB 707 Etu Uaisele – WG 710 Daniel Mortimer – FE 712 Jonathan Wright – CE 713 Shane Shackleton – SR 714 Justin Poore – PR 715 Justin Horo – SR 716 Tom Humble – FE 717 Pele Peletelese – PR In: Out: The following awards were awarded in the post-season:[3]