The Lions lost in their semi-final clash against the Western Bulldogs at the Melbourne Cricket Ground by 51 points.
The Lions continued to be active in the trade week and on the fourth day they secured St Kilda's Xavier Clarke.
Andrejs Everitt extended the Bulldogs' lead at the start of the final quarter, before Justin Sherman reduced the margin back to 5 points with his second goal.
An interchange infringement from Brisbane resulted in a 50-metre penalty and a nine-point supergoal, kicked by Ryan Griffen.
Jared Brennan cut the margin back to eight points, but that ended up being the final score.
Brisbane won its first game since round 10 and in the process avoided its first wooden spoon in twelve years whilst at the same time condemning the Eagles to their first ever last place finish.
Jonathan Brown played his 200th game and kicked four goals as Brisbane defeated Essendon in Melbourne for the first time in four attempts.