A total of sixty-four players have made their Australian Football League (AFL) debut in a senior AFL match to date during the 2010 AFL season.
In addition to those players making their AFL-level debuts, twenty-eight players have made their debuts following a trade or re-drafting are also listed below in a separate table.
A senior AFL match is an Australian rules football match between two clubs that are, or have been in the past, members of the AFL.
A senior AFL match is played under the laws of Australian football, and includes regular season matches, as well as finals series matches.
The list is arranged in the order in which each player made his debut for a club in a senior AFL match.