The 2010 CAF Champions League was the 46th edition of Africa's premier club football tournament organized by the Confederation of African Football (CAF), and the 14th edition under the current CAF Champions League format.

The winner, TP Mazembe qualified for the 2010 FIFA Club World Cup,[1] and also played in the 2011 CAF Super Cup.

1 Hearts of Oak, the champion of Ghana, did not enter the competition, citing financial problems.

Byes: Al Ahly (Egypt), Al-Hilal Omdurman (Sudan), ASEC Mimosas (Ivory Coast), Dynamos (Zimbabwe), Heartland (Nigeria), TP Mazembe (Congo DR), Africa Sports National (Ivory Coast, drawn against champions of Benin, but the Beninese FA did not send a team) and US Douala (Cameroon, drawn against the champions of São Tomé and Príncipe, but the São Tomé and Príncipe FA did not send a team).

The top scorers from the 2010 CAF Champions League are as follows: