Rookies in italics Roster updated November 22, 2010 51 Active, 7 Inactive y-denotes team has clinched a 2010 UFL championship game berth x-denotes team has been eliminated from championship contention at Rentschler Field, East Hartford, Connecticut

The first game in the second season of the UFL was a battle of the two teams that relocated during the offseason, the Sacramento Mountain Lions, formerly the California Redwoods, and the Hartford Colonials, formerly the New York Sentinels.

Hartford took scored the first 27 points of the game en route to the franchise's first victory in its two-year history, 27–10.

[2] A record-crowd of 14,384 attended the first professional football game in Hartford since 1973.

at Rentschler Field, East Hartford, Connecticut at Rentschler Field, East Hartford, Connecticut at Sam Boyd Stadium, Whitney, Nevada at Hornet Stadium, Sacramento, California at Citrus Bowl, Orlando, Florida at Rentschler Field, East Hartford, Connecticut