The 2010 Internazionali Femminili di Palermo was a women's tennis tournament played on outdoor clay courts.

It was the 23rd edition of the Internazionali Femminili di Palermo, part of the WTA International tournaments of the 2010 WTA Tour.

It took place in Palermo, Italy, from 12 July until 18 July 2010.

* Seedings are based on the rankings of July 5, 2010.

The following players received wildcards into the singles main draw The following players received entry from the qualifying draw: Kaia Kanepi defeated Flavia Pennetta, 6–4, 6–3 Alberta Brianti / Sara Errani defeated Jill Craybas / Julia Görges 6–4, 6–1