The 2010 Jacksonville Dolphins football team represented Jacksonville University in the 2010 NCAA Division I FCS football season.

The Dolphins were led by fourth-year head coach Kerwin Bell and played their home games at D. B. Milne Field.

They were a member of the Pioneer Football League.

They finished the season 10–1, 8–0 in PFL play to finish tied for first place.

They won their second PFL Championship in school history.