The 2022 St. Thomas Tommies football team represented the University of St. Thomas in Saint Paul, Minnesota as a member of the Pioneer Football League (PFL) during the 2022 NCAA Division I FCS football season.
Led by 14th-year head coach Glenn Caruso, the Tommies compiled an overall record of 10–1 with a mark of 8–0 in conference play, winning the PFL title.
St. Thomas was ineligible for the NCAA Division I Football Championship playoffs due to the program's transition from NCAA Division III.
Davidson received the PFL's automatic bid to the playoffs.
The Tommies played home games at O'Shaughnessy Stadium in Saint Paul, Minnesota.