2010 Quick-Step season

Its ridership is mostly unchanged from 2009, in spite of an offseason attempt to sign reigning Tour de France champion Alberto Contador.

Seeldraeyers, who had won the youth classification in the 2009 Giro d'Italia, was kept off the squad in favor of the Tour de France.

Pineau followed an early morning move from Bbox Bouygues Telecom rider Yukiya Arashiro, and they, along with Cofidis' Julien Fouchard formed the day's breakaway.

[9] In stage 11, when 50 riders formed the day's breakaway and the favorites lost more than 13 minutes, Cataldo nearly took the squad's third victory.

Unable to bridge up to an attacking Evgeni Petrov in the stage's final kilometer, Cataldo was second on the day.

[14] Samoilau was the squad's highest-placed rider in the final overall standings, in 39th place at a deficit of one hour and 46 minutes to Giro champion Ivan Basso.

Pineau won the Premio della Fuga classification for most kilometers spent in a breakaway of ten or fewer riders.

Pineau had also made the breakaway and won the first four climbs, giving him the polka-dot jersey as leader of the mountains classification, before he pulled up and rejoined the peloton behind them.

Chavanel's nearly four-minute gap over the peloton nonetheless stood, giving him the yellow jersey as well as the stage win.

[18][19] Chavanel was unable to maintain the race lead the next day in stage 3, which due to its inclusion of several cobbled sectors was expected to be very difficult and crash-ridden.

Chavanel again rode to the stage win and yellow jersey alone, with a gap of nearly a minute over Rafael Valls in second.

[25] In stage 16, Van de Walle and Barredo both made a nine-man breakaway, one which notably also included seven-time Tour champion Lance Armstrong, who had fallen well out of overall contention.

Their highest-placed rider in the final overall standings was De Weert, in 18th place at a deficit of just under 22 minutes to Tour champion Alberto Contador.