The Cougars played their home games at Bishop John D'Arcy Stadium and were members of the Mid-States Football Association (MSFA) Mideast League (MEL).
The Cougars finished in 2nd place in the MSFA MEL division, but they received an at-large bid to participate in the postseason NAIA playoffs.
10/23/2010 - With a 41-14 home win over Missouri U S&T, the 7th-ranked Cougars remained undefeated and avenged a 2-point loss on the road against last year's Miners.
Next week's game at #3 St. Xavier will match two undefeated, NAIA top-10 Cougar teams to decide the conference and division championships.
11/20/2010 - Ranked #10 in the final NAIA regular-season poll, USF drew a road trip to Lindenwood for the first round of the playoffs.
The Cougars pulled off the upset win, 44-38, with an offense that efficiently controlled the football for over 40 minutes of the 60-minute game.