The 2010 Serbia Open (also known as Serbia Open powered by Telekom Srbija for sponsorship reasons) was a men's tennis tournament played on outdoor clay courts.

It took place at the Milan Gale Muškatirović complex in Belgrade, Serbia, from 3 May through 9 May 2010.

The singles draw featured the tournament's host, ATP ranked No.

Other featured stars were 2010 Grand Prix Hassan II champion Stan Wawrinka, 2010 Regions Morgan Keegan Championships champion Sam Querrey and 2010 Heineken Open champion John Isner.

The following players received wildcards into the main draw: The following players received entry from the qualifying draw: Sam Querrey defeated John Isner, 3–6, 7–6(7–4), 6-4 Santiago González / Travis Rettenmaier defeated Tomasz Bednarek / Mateusz Kowalczyk, 7–6(8–6), 6–1