The 2010 Sony Ericsson Open (also known as the 2010 Miami Masters), was a tennis tournament for men and women held from March 22 to April 4, 2010.

[5] Other seeds that fell were Albert Montañés, Janko Tipsarević, Sam Querrey and Viktor Troicki who lost to David Nalbandian.

Juan Carlos Ferrero overcame a second lapse against John Isner winning 6−2, 3−6, 6−3, while compatriots Tommy Robredo and Feliciano López fell.

In the fourth round action Jo Wilfried Tsonga cruised over Juan Carlos Ferrero 6−2, 6−2 to set up a clash against Rafael Nadal who downed compatriot David Ferrer 7–6(5), 6–4.

The other Quarterfinal showdown is between Mikhail Youzhny who defeated Mardy Fish taking on Robin Söderling who won over Fernando González.

He is now scheduled to face Tomáš Berdych who upset Roger Federer 6–4, 6-7(3), 7-6(6) saving a match point en route to the victory.

[12] Following Nadal and Roddick in the semifinals was Tomáš Berdych who survived against Fernando Verdasco two days after defeating Roger Federer 4−6, 7−6(5), 6−4 with both players saving 7 of 9 break points.

[14] In the first semifinal saw Andy Roddick taking on Rafael Nadal with leading the head-to-head 5−2 with a 3 match winning streak and 7 straight sets.

[2] In the second round several seeds fell with Alona Bondarenko, Sabine Lisicki, Alisa Kleybanova, María José Martínez Sánchez, Anabel Medina Garrigues, Aleksandra Wozniak and Aravane Rezaï.

2010 Australian Open Chinese semifinalists Li Na, Zheng Jie and Elena Dementieva were also ousted.

The fourth round began with a major upset as Marion Bartoli won convincingly over top seed Svetlana Kuznetsova 6–3, 6-0 as the Russian struggled with a shoulder injury.

[22] Three Belgians advance to the Quarterfinals with relative ease Yanina Wickmayer defeated Timea Bacsinszky 6−0, 6−1, Justine Henin dominated Vera Zvonareva with a 6–4, 6–0 victory and Kim Clijsters prevailed over defending champion Victoria Azarenka 6−4, 6−0.

Kim Clijsters had an easier victory as she dispatched Australian Samantha Stosur 6–3, 7–5 in just over 70 minutes,[24] while Justine Henin needed twice as more time to grind over world no.

"It took a lot of hard work to get back into shape and I have a few people to thank, including my fitness coach and husband", Clijsters said during the on-court ceremony.

The older Williams stated that "Sometimes when you hit a few bad shots it's not as easy to reel it in, and things start to go a little bit quicker.

They were joined by half of the defending champion Andy Ram who partnered Michaël Llodra who fell to Feliciano López and Fernando Verdasco.

In the first round three seeded teams fell with Bethanie Mattek-Sands and Yan Zi who fell to Maria Kirilenko and Agnieszka Radwańska, Chuang Chia-jung and Hsieh Su-wei falling to Klaudia Jans and Vladimíra Uhlířová, and the biggest upset as top seeds Cara Black and Liezel Huber was upset by Natalie Grandin and Abigail Spears.

Defending champion Svetlana Kuznetsova partnered with Alicia Molik losing to Gisela Dulko and Flavia Pennetta.

2 seeds Nuria Llagostera Vives and María José Martínez Sánchez who fell to Gisela Dulko and Flavia Pennetta.

In the semifinals saw Nadia Petrova and Samantha Stosur advancing to the finals in a convincing fashion with a 6–1, 7–5 victory over Chan Yung-jan and Zheng Jie.

In the second semifinals saw Gisela Dulko and Flavia Pennetta upsetting 4th seeds Lisa Raymond and Rennae Stubbs in a straight set 6–4, 6–4 victory.

A record total of 312,386 visited the Crandon Park Tennis Center including a sellout crowd of 14,119 for the men's final on Sunday, April 4.