The 2010 Southeast Missouri State Redhawks football team represented Southeast Missouri State University as a member of the Ohio Valley Conference (OVC) during the 2010 NCAA Division I FCS football season.

Led by fifth-year head coach Tony Samuel, the Redhawks compiled an overall record of 9–3 with a mark of 7–1 in conference play, winning the OVC title.

Southeast Missouri State received an automatic bid to the NCAA Division I Football Championship playoffs, where the Redhawks lost in second round to the eventual national champion, Eastern Washington.

The team played home games at Houck Stadium in Cape Girardeau, Missouri.

2006 was the first and only winning season in Samuel's tenure as Southeast Missouri State's head coach.