The 2022 Southeast Missouri State Redhawks football team represented Southeast Missouri State University (SEMO) as a member of the Ohio Valley Conference (OVC) during the 2022 NCAA Division I FCS football season.

Led by ninth-year head coach Tom Matukewicz, the Redhawks played their home games at Houck Stadium in Cape Girardeau, Missouri.

Although Southeast Missouri State finished as OVC co-champions with UT Martin (both with 5–0 OVC records), SEMO was awarded the automatic bid to the 2022 FCS playoffs while UT Martin was not.

[1] Both teams had identical records in conference play, and no game had been played between the two teams that season, as a result of schedule changes to accommodate new member Lindenwood.

The tiebreaker to determine an automatic conference bid ultimately then came down to a coin flip, which the Redhawks won.