The 2010 Yemeni President Cup was the 13th edition of the Yemeni President Cup.
The cup winner were guaranteed a place in the 2011 AFC Cup.
First legs: May 27–June 11; Second legs: June 7–15 First legs: June 16–18; Second legs: June 20–22 First legs: June 23–25; Second legs: June 26–28 First legs: July 1–2; Second legs: July 6