The final was contested in a two-leg aggregate format on 18 and 25 April 2012, between two Mexican teams, Monterrey and Santos Laguna.

[2] As a result, Monterrey earned the right to represent CONCACAF at the 2012 FIFA Club World Cup, entering at the quarterfinal stage.

[4] Monterrey were the defending champions, winning the title in 2010–11 after beating Real Salt Lake in the final.

Santos Laguna defeated two teams from Major League Soccer in the knockout round, scoring 6 goals in each of the two home victories.

Both teams qualified for the CONCACAF Champions League tournament by reaching the final of the Torneo Apertura 2010 in which Monterrey won with a score of 5–3.