Conference play began with an upset loss at home to the Kansas State Wildcats on September 22 and concluded with a win against the TCU Horned Frogs in Fort Worth, Texas on December 1.

They faced former Big 12 member Texas A&M in the Cotton Bowl Classic, where they lost, 13–41.

[1] The Sooners were also the first team since Florida in 1993 to play against the top 3 Heisman vote-getters in the same season: Collin Klein of Kansas State, Manti Te'o of Notre Dame, and Johnny Manziel of Texas A&M (the Sooners only 3 losses on the season).

Following the season, Lane Johnson was selected 4th overall in the 2013 NFL draft, along with Landry Jones in the 4th round, Kenny Stills in the 5th, Justin Brown and Stacy McGee in the 6th, and David King in the 7th.

Sources: Roster Last update: September 2, 2012 at Sun Bowl Stadium, El Paso, Texas