The Itaipava São Paulo Indy 300 presented by Nestlé was the fourth race of the 2012 IZOD IndyCar Series season.

The race took place on April 29, 2012, on the 2.536-mile (4.081 km) temporary street circuit in São Paulo, Brazil, and was telecasted by the NBC Sports Network in the United States and TV Bandeirantes in Brazil.

1 Points include 1 point for pole position and 2 points for most laps led.