[1] The 36 teams were divided into six groups based on each separate region of Colombia.
The group winners and runners-up, along with the four best third-placed teams, advanced to the Round of 16.
Each tie in the knockout phase was played in home-and-away two-legged format.
In each tie, the team which had the better overall record up to that stage host the second leg, except in the round of 16 where the group winners automatically hosted the second leg.
In case of a tie in aggregate score, neither the away goals rule nor extra time was applied, and the tie was decided by a penalty shoot-out.