[15] These early enrollments included: quarterback Stephen Collier, wide receivers Johnnie Dixon and Curtis Samuel, offensive linemen Marcelys Jones and Kyle Trout, linebacker Raekwon McMillan, and kicker Sean Nuernberger.

Paul Keels headed the crew with play-by-play, Jim Lachey with color commentary, Marty Bannister as sideline and locker room reporter, and Skip Mosic as the pre-game and halftime show host.

[44][46] Virginia Tech received the ball to open the game, with the Buckeye defense forcing a turnover on an interception thrown by quarterback Michael Brewer to cornerback Eli Apple.

Both defenses continued to dominate the game, with Ohio State forcing the Hokies to punt on their next two possessions and Virginia Tech intercepting a pass from Barrett.

[45] Another Barrett interception returned for a touchdown with less than a minute remaining in the game, sealed 35–21 the upset victory for Virginia Tech, which also ended Ohio State's 25-game regular season win streak.

[51] A three and out by the Buckeye defense gave the ball back to the Ohio State offense, who then drove 65 yards and took a 14–0 lead on pass from Barrett to Rod Smith.

After driving deep into the Golden Flash territory, the Buckeye offense stalled and was forced to settle for a field goal early in the second quarter, giving Ohio State a 24–0 lead.

[58] On the first play of Cincinnati's ensuing possession, the Buckeye defense forced a fumble in the endzone, which was recovered by the Bearcats for a safety, extending Ohio State's lead to 16–7.

[56] Ohio State began to pull away late in the third quarter with another field goal and a 24-yard touchdown pass from Barrett to Dontre Wilson, expanding the Buckeyes lead to 43–28.

[57] A 34-yard touchdown pass from Barrett to Devin Smith early in the fourth quarter gave Ohio State a 50–28 lead and would be the last scoring play of the game.

[65] Maryland quarterback Caleb Rowe again led the Terrapins down the field and scored on a Stefon Diggs 4-yard touchdown reception on their first possession of the fourth quarter.

[74][76] The Nittany Lions received the opening kickoff and were stopped by the Buckeye defense, who forced an interception by Christian Hackenberg, which was recovered by Vonn Bell.

[77] The Ohio State defense forced their second Hackenberg interception on the Nittany Lions' ensuing possession, but were unable to put together to take advantage, eventually punting after a three and out.

[77] Penn State was unable to score on their ensuing possession, with Hackenberg being sacked on the final play of the game by Joey Bosa, sealing the victory for the Buckeyes.

[84] Ohio State scored on their next two drives with a field goal from Sean Nuernberger and a 32-yard touchdown pass from J. T. Barrett to Devin Smith, extending their lead to 17–0.

[85] After a 25-yard punt return late in the first half, Ohio State scored in two plays on a touchdown pass from Barrett to Devin Smith, giving the Buckeyes a 31–0 lead going into halftime.

[84] Ohio State, who received the opening kickoff of the second half, scored on an 8-play, 79-yard drive that ended in a touchdown pass from Cardale Jones to Dontre Wilson.

[87][89] Ohio State received the opening kickoff and drove 45 yards in nine plays and failed to score after a missed field goal from Sean Nuernberger.

[95] On the Buckeyes' ensuing possession, they drove 57 yards and ended the first half with a 22-yard field goal by Sean Nuernberger, giving Ohio State a 17–14 lead at halftime.

[99] The Buckeye defense forced an interception on the ensuing Golden Gopher drive, which was returned for 28 yards by Doran Grant, though the Ohio State offense failed to take advantage and score.

[105] Ohio State scored again on their ensuing offensive drive, on a four-yard touchdown pass from J. T. Barrett to Jeff Heuerman, giving the Buckeyes a 14–0 lead.

[109] Ohio State received the opening kickoff of the second half and drove 72 yards in 5 plays, capping the drive with another touchdown run from Barrett, giving the Buckeyes a 21–14 lead.

[111] The Buckeyes began to take control of the game early in the fourth quarter, on another Elliott touchdown run making the score 35–21 Ohio State.

[112][114] On Michigan's ensuing possession, the Buckeye defense sacked Gardner, with Joey Bosa forcing a fumble, which was returned 33 yards by Darron Lee for a touchdown, which gave Ohio State a 42–21 lead.

[111] Ohio State was able to run out the clock on their next possession, securing their third straight victory over the Wolverines' and a third consecutive undefeated Big Ten regular season.

[118] The next Buckeye possession also resulted in scores, with a 44-yard touchdown reception by Devin Smith from Cardale Jones and a 14-yard run from Elliott, extending the Ohio State lead to 31–0.

[120] The Buckeye defense forced the Wisconsin offense in the three and outs three times during the second quarter, and got a score on a fumble recovery, returned by Joey Bosa, which gave Ohio State a 38–0 lead going into halftime.

[129] The Buckeyes closed out the first half by scoring on a trick play, a 13-yard pass from Evan Spencer to Michael Thomas, cutting the Crimson Tide lead to 21–20 going into halftime.

[142] Ohio State turned the ball over on their first possession of the half on a Cardale Jones pass intercepted by Danny Mattingly returned to the Oregon 30-yard line.

[159] The event included a performance by the Ohio State University Marching Band, as well as speeches from athletic director Gene Smith, head coach Urban Meyer, Braxton Miller, and Ezekiel Elliott.