The 2015–16 Eurocup Basketball knockout stage was played from 23 February to 27 April 2016.
A total of 16 teams compete in the knockout stage.
In the knockout stage, teams played against each other over two legs on a home-and-away basis, with the overall cumulative score determining the winner of a round.
Thus, the score of one single game can be tied.
The first legs were played on 15 and 16 March, and the second legs were played on 22 and 23 March 2016.