The 2015–16 Euroleague Top 16 was played from 29 December 2015 to 7 April 2016.
A total of 16 teams competed in the Top 16 to decide the 8 places in the Playoffs.
In each group, teams played against each other home-and-away in a round-robin format.
Cedevita and Darüşşafaka Doğuş made their debut appearances in the Top 16 of the modern era of Euroleague Basketball.
If teams are level on record at the end of the Top 16, tiebreakers are applied in the following order: