Oklahoma finished conference play with an 8–1 record winning their ninth Big 12 Championship, their first since 2012.

Oklahoma met for the first time against the Akron Zips at home to open the season.

Roster Last update: October 5, 2015 at Gaylord Family Oklahoma Memorial Stadium • Norman, OK

at Bill Snyder Family Football Stadium • Manhattan, KS

The 2016 NFL draft was held at the Auditorium Theatre and Grant Park in Chicago on April 28–30, 2016.

The following Oklahoma players were either selected or signed as free agents following the draft.