The 2016–17 USC Upstate Spartans men's basketball team represented the University of South Carolina Upstate during the 2016–17 NCAA Division I men's basketball season.

The Spartans, led by 15th-year head coach Eddie Payne, played their home games at the G. B. Hodge Center in Spartanburg, South Carolina as members of the Atlantic Sun Conference.

They lost in the quarterfinals of the ASUN tournament to Kennesaw State.

This would be Eddie Payne's final season as head coach at USC Upstate, as he announced his retirement On October 3, 2017.

They lost in the quarterfinals of the A-Sun tournament to North Florida.