The 2021–22 USC Upstate Spartans men's basketball team represented the University of South Carolina Upstate in the 2021–22 NCAA Division I men's basketball season.

The Spartans, led by fourth-year head coach Dave Dickerson, played their home games at the G. B. Hodge Center in Spartanburg, South Carolina as members of the Big South Conference.

[1] The Spartans finished the 2020–21 season 5–18, 5–11 in Big South play, to finish in ninth place.

In the Big South tournament, they lost in the first round to High Point.

[2] Roster Last update: October 29, 2021 Source:[3]