The 2024–25 USC Upstate Spartans men's basketball team represents the University of South Carolina Upstate during the 2024–25 NCAA Division I men's basketball season.

The Spartans, led by first-year head coach Marty Richter, play their home games at the G. B. Hodge Center in Spartanburg, South Carolina as members of the Big South Conference.

[1] They were defeated by Radford in the first round of the Big South tournament.

[2] On March 25, 2024, head coach Dave Dickerson announced that he would be stepping down, in order to take the assistant head coaching position at Ohio State, a position he held prior to his hiring at USC Upstate.

[3] On April 5, the school announced that former Drake assistant coach Marty Richter would become the Spartans' new head coach.