The 2017–18 USC Upstate Spartans men's basketball team represented the University of South Carolina Upstate during the 2017–18 NCAA Division I men's basketball season.

The Spartans, led by first-year head coach Kyle Perry, played their home games at the G. B. Hodge Center in Spartanburg, South Carolina as members of the Atlantic Sun Conference.

They lost in the quarterfinals of the ASUN tournament to Florida Gulf Coast.

After the season, USC Upstate fired Perry on March 1, less than five months after being named full time head coach of the Spartans.

[3] On March 30, the school hired former Tulane head coach Dave Dickerson for the job.