The Colts got on the board with a 50-yard Adam Vinatieri field goal, but the Lions went up 21–3 on its next possession when Matthew Stafford hit Eric Ebron for a six-yard touchdown pass.
Indianapolis closed to 21–10 near the end of the first half after Andrew Luck tossed a two-yard touchdown pass to Donte Moncrief.
The Colts got within a field goal early in the third quarter with a 19-yard scoring strike from Luck to Dwayne Allen and a successful 2-point conversion.
On Detroit's next drive, Stafford connected with Ameer Abdullah on an 11-yard touchdown pass to put his team back up, 28–18.
The Lions regained the lead on a 13-yard touchdown pass from Stafford to Riddick, but Matt Prater missed the extra point.
That allowed Indianapolis to take a 35–34 lead on its next possession, when Luck again connected with Doyle, this time on a six-yard touchdown pass.
The Lions had led for most of the game, accumulating 12 points in the first half with an end zone tackle of DeMarco Murray by Devin Taylor for a safety, a 24-yard touchdown catch by Anquan Boldin from Matthew Stafford, and a 42-yard Matt Prater field goal, while holding the Titans to only a 46-yard field goal by Ryan Succop before the break.
After Tennessee gained a 16–15 lead late in the fourth quarter on touchdown passes from Marcus Mariota to Delanie Walker and Andre Johnson, from 30 and nine-yards respectively, an attempted Detroit comeback failed when Matthew Stafford was picked off by Perrish Cox in the closing seconds, giving the Lions their first loss of the season.
Green Bay accumulated a big lead with two touchdown catches by Jordy Nelson for eight and later 17 yards, one by Richard Rodgers from two-yards, as well as a 36-yard field goal from Mason Crosby.
After the break, the Lions attempted a comeback with touchdown catches by Anquan Boldin and Marvin Jones, from two and 45-yards respectively, as well a 50-yard Prater field goal.
The Lions responded with an 85-yard punt return by Andre Roberts, and a two-point conversion pass from Matthew Stafford to Golden Tate.
The Eagles responded in the second quarter with a one-yard touchdown pass from Carson Wentz to Ryan Mathews, cutting the Lions lead to seven points.
The Eagles responded with a 50-yard field goal from Caleb Sturgis, which made the score 21–10 in favor of the Lions at halftime.
At the 2:34 mark of the final quarter, Darius Slay forced a Ryan Mathews fumble, which the Lions recovered inside Eagles territory.
Detroit prevented the Rams from getting into range for a game-tying field goal when Rafael Bush intercepted a Keenum pass with just over a minute to play, giving the Lions a 31–28 win and improving their record to 3–3.
The Lions took the lead back on the next drive, when Matthew Stafford hit Anquan Boldin for an 18-yard TD with 16 seconds left, to win the game, 20–17.
First, Brock Osweiler connected with C. J. Fiedorowicz on a six-yard touchdown pass, then Lamar Miller scored on a one-yard run.
Detroit responded with a one-yard touchdown catch by Theo Riddick in the fourth quarter, but the Texans went back up by 10 points after a 36-yard Novak field goal.
Minnesota took a three-point lead via a one-yard touchdown run from Rhett Ellison with 23 seconds left in the game.
The Lions' first score came in the second quarter on a 55-yard punt return from Andre Roberts, but the extra point try by Matt Prater was partially blocked and failed.
The Jaguars responded with a three-yard touchdown pass from Blake Bortles to Allen Robinson, but the conversion attempt by Myers also failed.
The Jaguars responded with 10 points in the third quarter via a 52-yard field goal from Myers, and a three-yard touchdown pass from Bortles to Marqise Lee, giving them a 19–16 lead.
The Lions offense scored its first and only touchdown on a one-yard run from Eric Ebron, and Matt Prater added a 43-yard field goal with 22 seconds left in the game.
[65] The Lions extended their own NFL record of games to start a season being decided by seven points or fewer, now standing at eleven.
Detroit extended their lead in the second quarter via a one-yard touchdown pass from Matthew Stafford to Theo Riddick.
The Giants extended their lead in fourth quarter with a four-yard touchdown pass from Manning to Odell Beckham Jr.
The Lions' attempted comeback failed when Matthew Stafford was picked off by Dominique Rodgers-Cromartie in the end-zone for a touchback with 2:09 left in the game, losing 17–6, and snapping their five-game winning streak.
To finish the regular season, the Lions hosted a rematch with division rival the Green Bay Packers on Sunday Night Football, their second consecutive nationally televised, prime-time game.
The Lions responded with a 54-yard field goal from Matt Prater and a 35-yard touchdown pass from Stafford to Anquan Boldin but came up short, losing 24–31.
The loss marked the Lions' ninth consecutive playoff game without a win, the longest streak in NFL history.