After losing six games where they had late fourth-quarter leads in 2015, Jerry Reese spent over $200 million in free agency to revitalize their defense.

He re-signed Jason Pierre-Paul to a one-year deal and signed Damon Harrison, Olivier Vernon and Janoris Jenkins.

The Giants began 2–0 before falling into a three-game losing streak to the Washington Redskins, Minnesota Vikings and Green Bay Packers.

Despite losing to the Philadelphia Eagles in Week 16, the Tampa Bay Buccaneers' loss to the New Orleans Saints two days later meant the Giants clinched a playoff trip for the first time since their last Super Bowl season in 2011.

The Giants' first playoff game since Super Bowl XLVI ended in disappointment, as they were upended by the Green Bay Packers 38–13 in the Wild Card round at Lambeau Field.

Several media outlets criticized Giants' wide receivers Victor Cruz, Odell Beckham Jr., Sterling Shepard and Roger Lewis after a picture surfaced on social media of the players on vacation on a boat in Miami with rapper Trey Songz a week before the playoff game against the Green Bay Packers.

Victor Cruz played his first NFL game in 700 days and the Giants fought hard with rookies Dak Prescott and Ezekiel Elliott in their pro debuts.

On the last play of the game, Cowboys wide receiver Terrance Williams caught a pass that put Dallas near field goal range but chose to stay in bounds to get extra yards.

The Giants led 7-3 at halftime, their only score coming from a field goal blocked by Johnathan Hankins which Janoris Jenkins returned for a touchdown.

This was a highly anticipated game after the Redskins added Josh Norman and would be the first time facing Odell Beckham Jr. since their incident the prior season.

After Eli Manning threw an interception early in the fourth quarter, Beckham was seen striking the kicking net in frustration.

The push was his second unsportsmanlike conduct penalty, causing an automatic ejection under a new rule that the NFL had implemented in the aftermath of the previous incident between Beckham and Norman.

Larry Donnell fumbled on the first play from scrimmage and the Rams scored 10 quick points only to be shut out by a dominant Giants defense.

The Giants quickly took a 14-point lead after rookie Carson Wentz threw two interceptions on his first two drives and Eli Manning capitalized with touchdown passes to Odell Beckham Jr. and Roger Lewis.

After their win over the Eagles, the Giants stayed at home for a Monday night matchup against the Cincinnati Bengals, who were coming back from London after their tie against the Redskins.

Tom Coughlin, Justin Tuck, and Ernie Accorsi were inducted into the Giants Ring of Honor at halftime nursing a 14-10 lead.

Jay Cutler threw a late interception to Landon Collins - his final pass as a Chicago Bear - to seal the win.

The Giants played a conservative game and their defense recorded a season-high six sacks in their win over the Browns, their sixth in a row.

Rookie Eli Apple was a bright spot for the Giants, recording both his first career fumble recovery and interception in the 3rd quarter.

Trailing 7-3 in the third quarter, Leon Hall intercepted Prescott and Manning threw a 61-yard touchdown pass to Odell Beckham Jr. two plays later, which would be the game-winner.

While leading 10-6 in the 4th quarter, Odell Beckham Jr. had a signature one-handed touchdown catch and an interception by Dominique Rodgers-Cromartie sealed the 17-6 victory.

Despite the loss, the Giants clinched a playoff berth when the Tampa Bay Buccaneers fell to the New Orleans Saints 31–24 two days later.

On a late drive in the 4th quarter, Eli Manning connected with Tavarres King for 44 yards which set up a Josh Brown field goal.

The Giants were set to play the Green Bay Packers at Lambeau Field after they defeated the Detroit Lions later that night to win the NFC North title.