The 2016 season was the Green Bay Packers' 96th in the National Football League (NFL), their 98th overall and their 11th under head coach Mike McCarthy.

The team clinched the NFC North for the fifth time in six years with their week 17 win over the Detroit Lions.

They routed the fifth-seeded New York Giants 38–13 in the wild card round of the playoffs and defeated the top-seeded and heavily favored Dallas Cowboys 34–31 in the divisional round of the playoffs, but their season came to an end when they were beat by the second-seeded Atlanta Falcons in the NFC Championship Game 44–21.

On February 16, the NFL announced that the Packers would play the Indianapolis Colts in the Pro Football Hall of Fame Game.

The game would have occurred on Sunday, August 7, at Tom Benson Hall of Fame Stadium in Canton, Ohio, but was cancelled due to field conditions.

Despite Aaron Rodgers throwing for 4 touchdowns and the team holding a 32–26 lead with less than a minute left in the game, Matt Ryan threw a game-sealing touchdown pass to wide receiver Mohamed Sanu to stun Green Bay.

Aaron Rodgers, with his 3:0 TD-INT ratio in this game, posted a 150.8 passer rating, the highest allowed by the Seattle defense (which was without safety Earl Thomas, who was out for the year with a broken leg) since Pete Carroll became the Seahawks' head coach in 2010. at Soldier Field, Chicago

Aaron Rodgers then threw a 60-yard pass to Jordy Nelson to set up a Mason Crosby field goal to win 30–27 and improve to 8–6.

The Packers tied the series with the Bears for the first time since 1933. at Lambeau Field, Green Bay, Wisconsin

The Packers successfully ran the table as they improved to 10–6 and won the NFC North, matching last year's record.

The Giants had one of the best defenses in the NFL going into the game, but Rodgers threw for 4 touchdowns, including a 42-yard Hail Mary pass to Cobb at the end of the first half as the Packers would lead 14–6.

Dallas clinched the #1 seed as well as home-field advantage, but the Packers were able to prevail and upset the Cowboys with a Mason Crosby field goal as time expired 34–31.

This would later be surpassed with the 27-0 halftime deficit the Packers would face in the 2019 NFC Championship, which resulted in a 37-20 loss to the San Francisco 49ers.