The 2016 season was the Los Angeles Rams' 79th in the National Football League (NFL), and their fifth and final under head coach Jeff Fisher.

The Rams decided from 2016 to 2019 to return to wearing white uniforms at home in Los Angeles as a nod to the Fearsome Foursome era.

In Week 15 against the Seattle Seahawks, their NFC West divisional rival, the Rams wore white horns on their helmet just for the one game only, a move which would be repeated for the entire following season.

Running backs (RB) Wide receivers (WR) Tight ends (TE) Defensive linemen (DL) Defensive backs (DB) Special teams Reserve On November 25, 2015, the NFL announced that the Rams would play host to a then-undetermined NFC East opponent in the International Series, in the first-ever game at Twickenham Stadium in London, United Kingdom.

On January 3, 2016, the New York Giants were confirmed as the Rams' opponent for this game, both teams having finished in third place in their respective divisions in the 2015 season.

Playing at home in the Los Angeles Memorial Coliseum for the first time since 1979, the Rams got the victory in a defensive battle over their NFC West rivals.

Robert Quinn and William Hayes both had sacks of Seahawks quarterback Russell Wilson, while Alec Ogletree had nine tackles and a fumble recovery on Seattle's final drive to preserve the victory.

Case Keenum connected twice for touchdown passes to Brian Quick as Los Angeles held on for the victory, which gave the Rams a 3–1 start for the first time since 2006.

Case Keenum passed for three touchdowns and ran for another, but an interception in the final minutes ruined a comeback attempt as the Rams fell to 3–3 with a loss to the host Lions.

Tied 14–14 with four seconds remaining in the first half, the Rams failed to take the lead as Todd Gurley (14 carries, 58 yards) was stopped short of the goal line as time ran out.

Linebacker Alec Ogletree and cornerback Troy Hill each had seven solo tackles to share the team lead for the defense, which got no sacks as the Rams dropped to a 3–4 record going into the bye week.

Midway through the fourth quarter, Rams quarterback Case Keenum, who passed for 296 yards, drove his team to the Carolina 7-yard line, but his third down pass to tight end Lance Kendricks (team-high seven receptions, 90 yards) was dropped at the goal line, forcing the Rams to settle for a Greg Zuerlein field goal.

In the final minutes, the Rams drove 75 yards in 15 plays when Keenum connected with wide receiver Kenny Britt for a 10-yard touchdown with 34 seconds remaining to close to within 13–10, but the Panthers recovered the onside kick and then ran out the clock.

Early in the fourth quarter with the score tied and the Rams facing 4th-and-1 from their own 17, All-Pro punter Johnny Hekker boomed a career-long 78-yard punt that pinned the Jets inside the 20.

Hekker, who averaged 51.7 yards on seven punts, was named NFC Special Teams Player of the Week for his pivotal role in changing the Rams' fortunes on the day.

Linebacker Alec Ogletree, who had a team-high nine tackles, picked off a Bryce Petty pass at the two-minute warning to preserve the win, as the Rams improved to 4–5 without scoring a touchdown.

Despite being sacked four times, Miami quarterback Ryan Tannehill threw touchdown passes to Jarvis Landry and DeVante Parker, the last coming with just 36 seconds remaining in the game to take the 14–10 win.

New Orleans then scored 21 unanswered points before the Rams responded with Goff connecting with Lance Kendricks from 15 yards out with 55 seconds remaining in the period to bring Los Angeles to within 28–21.

Some would see the Saints running up the score as a measure of revenge against their former defensive coordinator Gregg Williams, the main responsible for Bountygate, who now held that position with the Rams.

The Rams offered little resistance on the road against the eventual Super Bowl champions, which held visiting Los Angeles to just 162 yards in total offense.

Meanwhile, Rams rookie quarterback Jared Goff struggled greatly, throwing two interceptions in the first half, the second of which was returned 33 yards for a touchdown by linebacker Deion Jones and a 21–0 Falcons lead.

On Atlanta's first possession of the third period, Ryan found wide receiver Taylor Gabriel for a 64-yard touchdown pass play and Coleman added another score on a 6-yard TD run.

The Rams salvaged some dignity in the fourth quarter with short touchdown runs by Goff and Todd Gurley, but the outcome of the game had long been decided.

"[29] The loss (in which Los Angeles was mathematically eliminated from postseason contention) was the 165th of Jeff Fisher's career, tying him with Dan Reeves for the most in NFL history.

Just three days after being named interim head coach, John Fassel led the Rams into their final road game of the season.

Additionally, Los Angeles switched to gray facemasks and went with white horns on their blue helmets for the first time since the 1972 NFL season.

In a matchup of two of the NFL's worst teams, Los Angeles started fast but faded in the fourth quarter as the 49ers, who had shut out the Rams in Week 1, snapped their own 13-game losing streak with a victory in the final minute.

Both teams held each other scoreless in the second and third periods, but it seemed that the Rams would outlast their rivals in the fourth when quarterback Jared Goff connected with fellow rookie tight end Tyler Higbee for a 2-yard touchdown with 10:38 remaining to build a 21–7 lead.

Then after the Rams were held to a three-and-out, Kaepernick drove San Francisco 75 yards in 10 plays, firing a 10-yard touchdown pass to wide receiver Rod Streater with 36 seconds remaining.

Arizona quarterback Carson Palmer, who won the Heisman Trophy while playing at USC, had a successful day in his return to the Coliseum, passing for 255 yards and three touchdowns as the Cardinals scored 28 unanswered points in the second half.