The team was led by head coach Bob Stoops, offensive coordinator Lincoln Riley, and defensive coordinator Mike Stoops, as well as such players as Mark Andrews, Orlando Brown, Jordan Evans, Baker Mayfield, Joe Mixon, Ogbonnia Okoronkwo, Samaje Perine, and Dede Westbrook.

Oklahoma did play in the 2017 Sugar Bowl against the Auburn Tigers, winning handily, 35–19.

Quarterback Tailback Wide receiver Long snappers Fullback Offensive lineman Defensive line Linebacker Defensive backs Placekicker Oklahoma announced their 2016 football schedule on November 24, 2015.

The Sooners will host two non-conference games against Louisiana–Monroe and Ohio State and travel to Houston, Texas to play Houston in NRG Stadium, a non-conference game at a neutral site.

Kickoff was delayed from the original start time of 6:30 p.m. to 8:00 p.m. due to lightning and thunderstorms in the vicinity of the University of Oklahoma.

The following Oklahoma players were either selected or signed as free agents following the draft.