The 2018–19 CAF Champions League knockout stage were played from 6 April to 31 May 2019.
The team that scored more goals on aggregate over the two legs advanced to the next round.
If away goals were also equal, then extra time was not played and the winners were decided by a penalty shoot-out (Regulations III.
[3] The bracket of the knockout stage was determined as follows:[2] The bracket was decided after the draw for the knockout stage (quarter-finals and semi-finals), which was held on 20 March 2019, 20:00 CAT (UTC+2), at the Marriot Hotel in Cairo, Egypt.
In the semi-finals, the four quarter-final winners played in two ties, with the matchups and order of legs decided by draw.