The 2018–19 CAF Confederation Cup knockout stage will be played from 7 April to 26 May 2019.
[1] A total of eight teams will compete in the knockout stage to decide the champions of the 2018–19 CAF Confederation Cup.
If the aggregate score is tied after the second leg, the away goals rule will be applied, and if still tied, extra time will not be played, and the penalty shoot-out will be used to determine the winner (Regulations III.
[3] The bracket of the knockout stage is determined as follows:[2] The bracket was decided after the draw for the knockout stage (quarter-finals and semi-finals), which was held on 20 March 2019, 19:00 CAT (UTC+2), at the Marriot Hotel in Cairo, Egypt.
In the semi-finals, the four quarter-final winners played in two ties, with the matchups and order of legs decided by draw.