The 2018 CAF Champions League knockout stage was played from 14 September to 9 November 2018.
If the aggregate score was tied after the second leg, the away goals rule would be applied, and if still tied, extra time would not be played, and the penalty shoot-out would be used to determine the winner (Regulations III.
[1] Effective from the Champions League group stage, weekend matches were played on Fridays and Saturdays while midweek matches were played on Tuesdays, with some exceptions.
[3] The bracket of the knockout stage was determined as follows:[2] The bracket was decided after the draw for the knockout stage (quarter-finals and semi-finals), which was held on 3 September 2018, 20:00 EET (UTC+2), at the CAF headquarters in Cairo, Egypt.
In the semi-finals, the four quarter-final winners played in two ties, with the matchups and order of legs decided by draw.