The Panthers played their home games at the Riccardo Silva Stadium in University Park, Florida as members of the East Division of Conference USA (C–USA).

Invitations include: Brad Muhammad (DB), Pharoah Mckever (TE) and Anthony Wint (LB).

[3] Notable departures from the 2017 squad included: Panthers who were picked in the 2018 NFL Draft: Listed in the order that they were released Conference USA released their preseason all-CUSA team on July 16, 2018 with the Panthers having two players selected.

[6] Offense Jordan Budwig – OL Defense Fermin Silva – DL

Conference USA released their preseason media poll on July 17, 2018, with the Panthers predicted to finish in fourth place in the East Division.