The Roadrunners played their home games at the Alamodome in San Antonio, TX, and competed in the West Division of Conference USA (C–USA).

They were led by third-year head coach Frank Wilson.

Conference USA released their preseason all-CUSA team on July 16, 2018, with the Roadrunners having two players selected.

[4] Defense Kevin Strong – DL Josiah Tauaefa – LB Conference USA released their preseason media poll on July 17, 2018, with the Roadrunners predicted to finish in fifth place in the West Division.

UTSA head coach Frank Wilson said, "Unfortunately we did not always execute to the fullest, but I think take away a couple of big-play opportunities, they weren't going methodically down the field and just shoving us around.