The team is led by Lincoln Riley, who is in his second year as head coach.

In the final College Football Playoff rankings of the season, Oklahoma was ranked fourth, earning them a spot in the 2018 Orange Bowl, in a national semi-final game against first-seeded Alabama.

The Sooners lost to the Crimson Tide, 34–45, marking the sixth consecutive loss for the school in CFP semi-finals or BCS national championship games.

Sooners quarterback Kyler Murray, following in the wake of Heisman Trophy winner Baker Mayfield, earned several national honors himself, including winning the school's second consecutive and seventh overall Heisman Trophy.

[15] Quarterback Running backs Wide receiver Tight ends Long snappers Offensive lineman Defensive lineman Linebacker Defensive backs Placekickers Punter

[19] Oklahoma's new defensive coordinator Ruffin McNeill was able to simplify the defensive plan which helped turn out good results against Texas Christian in the previous week with a Sooner victory 52-27.