The 2019–20 season was Guadalajara's third competitive season and third season in the Liga MX Femenil, the top flight of Mexican women's football.

The season started under a new manager, Ramón Villa Zevallos, who won the Clausura 2019 tournament with Tigres UANL.

[1] Guadalajara finished fifth on the Apertura tournament, qualifying for the playoffs; but were eliminated right away on quarterfinals by rivals América.

[2] Guadalajara started the new tournament with a positive balance.

Nevertheless, on 22 May 2020, the Clausura tournament was canceled due to the COVID-19 pandemic; in that moment Guadalajara was ranked third.