América de Cali won their first league title following a 3–2 win on aggregate against Independiente Medellín in the finals.
[1] Atlético Huila were the defending champions, but were eliminated by the eventual runners-up Independiente Medellín in the semifinals.
On 15 June 2019, DIMAYOR and the FCF announced an agreement with CONMEBOL for an additional berth for Colombia into the Copa Libertadores Femenina, which was awarded to the league runners-up.
Alianza Petrolera, Bogotá, Deportes Quindío, Envigado, Patriotas, Real Cartagena, and Unión Magdalena did not field a team in this edition, whilst Deportivo Cali, Independiente Medellín, Millonarios, and Once Caldas competed for the first time.
It ended on 18 August with the top teams from each group as well as the three best runners-up advancing to the knockout stage.