[1] Flamengo defeated defending champions River Plate in the final by a 2–1 score to win their second Copa Libertadores title.

In 2016, CONMEBOL proposed that the Copa Libertadores final to be played as a single match instead of over two legs.

[2] It was only on 23 February 2018 that CONMEBOL was able to confirm that starting from this edition, the final will be played as a single match at a venue chosen in advance,[3] and on 11 June 2018 after its Council meeting in Moscow, the confederation confirmed that the final would be played on 23 November 2019.

[4] On 14 August 2018, CONMEBOL announced that the 2019 final would be played in Santiago, Chile at the Estadio Nacional Julio Martínez Prádanos,[5] however, due to safety concerns derived from the 2019 Chilean protests, and after consultations with the finalist clubs and their respective football associations, CONMEBOL announced on 5 November 2019 that the match was moved to the Estadio Monumental in Lima, Peru.

[6] The following 47 teams from the 10 CONMEBOL member associations qualified for the tournament:[7] The entry stage is determined as follows:[7] The schedule of the competition was as follows.

[20] The first stage matches were played on Tuesday, Wednesday, and Thursday instead of Monday and Friday in the last two seasons.

The draw for the round of 16 was held on 13 May 2019, 20:30 PYT (UTC−4), at the CONMEBOL Convention Centre in Luque, Paraguay.

If still tied, extra time was not played, and a penalty shoot-out was used to determine the winner (Regulations Article 29).