Two-time defending champion Rafael Nadal defeated Dominic Thiem in a rematch of the previous year's final, 6–3, 5–7, 6–1, 6–1 to win the men's singles tennis title at the 2019 French Open.

[1] With the win, Nadal broke the all-time record for the most singles titles by a player at the same major (previously shared with Margaret Court, who won the Australian Open eleven times).

[5] The first round match between Ivo Karlović (40 years and three months) and Feliciano López (37 years and 8 months) was the oldest French Open men's singles match in terms of combined ages in the Open Era.

[8] It was the first time since the 2013 Australian Open that the top four seeds (Djokovic, Nadal, Federer, and Thiem) all reached the semifinals of a major, and the first time since the 2012 French Open that the Big Three all reached the semifinals of a major.

This marked the final major appearance of 2009 US Open champion Juan Martín del Potro, who lost to Karen Khachanov in the fourth round.