The 2019 Jacksonville State Gamecocks football team represented Jacksonville State University as a member of the Ohio Valley Conference (OVC) during the 2019 NCAA Division I FCS football season.

Led by sixth-year head coach John Grass, the Gamecocks compiled an overall record of 6–6, with a mark of 3–5 conference play, tying for fifth place in the OVC.

The OVC released their preseason coaches' poll on July 22, 2019.

[1] The Gamecocks had seven players at seven positions selected to the preseason all-OVC team.

[2] Offense Zerrick Cooper – QB Josh Pearson – WR Trae Berry – TE Darius Anderson – OG Hunter Sosebee – OT Defense Jalen Choice – LB Marlon Bridges – DB