The 2019 Tennessee State Tigers football team represented Tennessee State University as a member of the Ohio Valley Conference (OVC) in the 2019 NCAA Division I FCS football season.

Tennessee State finished the season 3–9 overall and 2–6 in OVC play to tie for seventh place.

The OVC released their preseason coaches' poll on July 22, 2019.

[2] Offense Chris Rowland – WR Thomas Burton – C Raekwon Allen – OG Defense Dajour Nesbeth – DB

On August 20, 2019, it was announced that starting quarterback Demry Croft had been charged with six counts of felony rape and two counts of sexual battery, from an incident that took place on December 1, 2018.