The 2019 Louisville Cardinals baseball team represented the University of Louisville during the 2019 NCAA Division I baseball season.

The Cardinals played their home games at Jim Patterson Stadium as a member of the Atlantic Coast Conference.

They were led by head coach Dan McDonnell, in his thirteenth year at Louisville.

All rankings from Collegiate Baseball on the date of the contest.

"()" represents postseason seeding in the ACC Tournament or NCAA Regional, respectively.