Roger Federer defeated the defending champion John Isner in the final, 6–1, 6–4 to win the men's singles tennis title at the 2019 Miami Open.

It was Federer's fourth Miami Open title, his 28th and final Masters singles title, and his 101st career singles title overall.

[1] Félix Auger-Aliassime became the youngest men's singles semifinalist in the tournament's 35-year history, and the first teenage semifinalist since Andy Murray and Novak Djokovic in 2007.

[2] All seeds received a bye into the second round.

Click on the seed number of a player to go to their draw section.