Oklahoma began the year ranked fourth in the AP Poll and were the overwhelming favorites to repeat as Big 12 Conference champions.

The Sooners fell to the Tigers, 63–28, to end the season at 12–2, and were ranked seventh in the final AP Poll.

The Sooners were led on offense by quarterback Jalen Hurts, a graduate transfer from Alabama that had previously played in three separate College Football Playoffs with the Crimson Tide.

Listed in the order that they were released The 2019 Big 12 media days were held July 15–16, 2019 in Frisco, Texas.

In the Big 12 preseason media poll, Oklahoma was predicted to finish atop the standings for the fourth consecutive year.

The Sooners will host 2 non-conference games against Houston and South Dakota, and will travel to UCLA.

[20] Oklahoma's cornerback Parnell Motley was ejected from the game for unsportsmanlike conduct after kicking a Kansas State player.

Kansas State's Eric Gallon forced a key fumble on a kick return but in process suffered a severe knee injury and he missed the rest of the game.

Oklahoma nearly came back in the fourth quarter but the game concluded after an on-side kick for a 48–41 final score and Kansas State win.

Predictions call that the Oklahoma Defense will need to slow the Cyclone offense to win the game.

Key: POS: Position, SOLO: Solo Tackles, AST: Assisted Tackles, TOT: Total Tackles, TFL: Tackles-for-loss, SACK: Quarterback Sacks, INT: Interceptions, PD: Passes Defended, FF: Forced Fumbles, FR: Fumbles Recovered, BLK: Kicks or Punts Blocked, SAF: Safeties