The 2020–21 California United Strikers FC season was the club's second in the National Independent Soccer Association (NISA) and second as a professional team overall.
Source: Match reports All eight NISA teams qualified for the 2020 Fall tournament, which will be hosted at Keyworth Stadium in Detroit, Michigan, beginning on September 21 ending with the final on October 2.
The Spring Season schedule was announced on March 18 with each association member playing eight games, four home and four away, in a single round-robin format.
Source: Match reports As a team playing in a recognized professional league, the Strikers would normally be automatically qualified for the U.S. Open Cup.
[28] On March 29, U.S. Soccer announced 2020 Fall Champion Detroit City FC as NISA's representative in the tournament.